TY - JOUR
T1 - Comprehensive Analysis of Neocytin: Physico-Chemical Properties and Toxicological Effects
AU - Ahmed El-Kholy
AU - Nour Abdelrahman
AU - Karim Hassan
AU - Mona Saad
JF - EAMD 3
Y1 - 0
VL - 0
IS - 0
SP - 105
N2 - By the mid-20th century, the growing ineffectiveness of sulfonamides and antibiotics in treating bacterial infections led to the emergence of numerous antibiotic-resistant strains. In response, efforts have focused on developing new chemotherapeutic agents, modifying existing antibiotics, and employing enzyme inhibitors to counteract resistance mechanisms. Neocytin is a multicomponent chemotherapeutic formulation composed of tetracycline, levomycetin, novocaine, and ascorbic acid. This study investigates the physico-chemical properties of Neocytin and assesses its toxicological profile, including acute and chronic toxicity, irritant effects, and impact on mucous membranes. Additionally, its influence on body weight in animal models was evaluated. The findings indicate that Neocytin is a low-toxicity agent for warm-blooded animals, exhibiting mild acute toxicity at a dose of 0.3 ml/kg, and is classified as a Class IV hazardous substance (minor hazard). Long-term administration at doses 3–5 times therapeutic levels did not adversely affect animal health, clinical status, metabolic function, or the integrity of vital organs and tissues.
UR - https://pubsys.eshragh.co/c718285494
ER -