TY - JOUR
T1 - Exploring the Cardioprotective Role of Quercetin against Doxorubicin-Induced Toxicity in Rats
AU - Fatima Zahra Amrani
AU - Youssef Benali
AU - Samira El-Haddad
JF - EAMD 3
Y1 - 0
VL - 0
IS - 0
SP - 71
N2 - Doxorubicin, an anthracycline, is a potent anti-cancer drug; however, its clinical use is hindered by its acute and chronic side effects, particularly cardiotoxicity. This study aimed to assess the protective effects of quercetin on doxorubicin-induced cardiotoxicity. Wistar rats were divided into five groups: a control group receiving saline (1 mL/kg), a quercetin control group receiving DMSO (1 mL/kg), a quercetin group receiving quercetin (20 mg/kg), a doxorubicin group receiving doxorubicin (25 mg/kg) intraperitoneally for three days, and a pretreatment group receiving quercetin (20 mg/kg) for 14 days before being treated with doxorubicin (25 mg/kg). After 14 days, the rats’ weights were recorded, and heart tissue samples were collected for histopathological examination. The results revealed significant weight loss in the doxorubicin-treated animals (P < 0.05), while quercetin pretreatment prevented the weight loss. Pathological analysis showed that quercetin protected the heart tissue from doxorubicin-induced damage. Overall, this study suggests that quercetin pretreatment effectively prevents doxorubicin-induced cardiotoxicity, likely due to its antioxidant properties.
UR - https://pubsys.eshragh.co/r304679722
ER -