TY - JOUR
T1 - Investigations on the Cytotoxic Effects of Excess ZnSO4 on Cell Division
AU - Hiroshi Tanaka
AU - Yuki Sato
AU - Kenji Mori
AU - Rina Okabe
JF - EAMD 3
Y1 - 0
VL - 0
IS - 0
SP - 117
N2 - Zinc is a crucial element for both plant and human growth, playing a key role in cell division and supporting the maintenance of normal cellular processes. This study investigates the effects of zinc on mitotic division at various concentrations and time points. By assessing the correlation between the mitotic index (MI), chromosomal aberrations (IAC), and exposure time to different concentrations of zinc sulfate (ZnSO4), the cytotoxic effects of ZnSO4 were evaluated. The results showed a strong positive correlation (r > 0.89) between the incidence of chromosomal aberrations and higher concentrations of ZnSO4, suggesting that increased zinc levels contribute to chromosomal damage. Furthermore, increasing exposure time from 24 to 72 hours and concentrations from 10 ppm to 50 ppm resulted in a significant negative correlation (r = -0.84). These results highlight the critical role of zinc in cellular function and the potential harm from excessive zinc‎.
UR - https://pubsys.eshragh.co/w103984664
ER -