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This study examines the acute toxicity of Monizen® forte when administered to white male mice through intragastric and subcutaneous routes. The evaluation of acute toxicity parameters for MONIZEN® forte was performed at the pharmacology and toxicology laboratory and vivarium of VNIIVSGE, affiliated with the FGBNU FNC VIEW RAN. The toxicological testing followed the protocol outlined in the “Guidelines for conducting preclinical studies of drugs. Part one” (2012).The median lethal dose (LD50) of MONIZEN® forte was found to be 2524 ± 91.5 mg/kg for subcutaneous injection in white nonlinear mice, whereas the oral (intragastric) administration showed an LD50 of 953.82 ± 156 mg/kg. According to the acute toxicity results in mice after a single intragastric dose, MONIZEN® forte is categorized as a moderately toxic compound under the 3rd hazard class in line with the hygienic classification GOST 12.1.007-76. Administering doses higher than recommended via either oral or parenteral routes caused toxic effects on the liver and kidneys in the tested mice.

This paper presents the findings of multiple investigations into the newly developed Bentorb sorbent, derived from winemaking byproducts, specifically the adhesive residues of yellow blood salt. Elemental analysis revealed that the predominant components of Bentorb include oxygen, carbon, silicon, aluminum, iron, nitrogen, and magnesium, which together make up the majority of the sorbent’s composition. Toxicological assessments of Bentorb were conducted using laboratory animals. To evaluate acute toxicity, 60 white mongrel rats, each weighing approximately 237 ± 7 g, were subjected to the substance. The results showed no significant changes in the general clinical condition of rats in either the experimental or control groups, and all animals survived the tests. Chronic toxicity was assessed in 60 white mice and 40 Wistar rats, each weighing 185 ± 12 g. Over the study period, no notable differences in health or survival rates were observed between the experimental and control groups. The effects of Bentorb on gastrointestinal function were examined in piglets aged 40-80 days. Additionally, the potential embryotoxicity of Bentorb was investigated in pregnant Wistar rats weighing 200-240 g. The study also included analyses of body weight and various internal organs in both control and experimental groups that received Bentorb.