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Royal jelly, a secretion produced by bees, has been previously shown to have beneficial effects on the nervous system. This study aimed to explore its potential in alleviating anxiety and controlling seizures in mice. To assess its anti-convulsant properties, 25 male mice were divided into 5 groups, with strychnine administered 30 minutes after royal jelly treatment to induce seizures. Key outcomes, including seizure onset and duration and mortality rates, were measured. A separate group of 35 male mice was used to evaluate the anxiolytic effect. Statistical analysis was performed using one-way ANOVA, considering P < 0.05 as significant. The results demonstrated that royal jelly doses of 200 and 400 mg/kg significantly delayed seizure onset and reduced seizure duration compared to the control group. In addition, the mortality rate in these groups was significantly lower than in the control group (P < 0.05). In the anxiety test, royal jelly doses of 50 and 100 mg/kg notably increased the stopping time and the number of entries into the maze arms compared with the control group (P < 0.05). These findings suggest that royal jelly effectively reduces seizures induced by strychnine and has potential anxiolytic effects in mice.