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This study assesses the risk of severe hyperlactatemia (defined as lactate levels > 4 mmol/L) in patients undergoing chronic low-dose aspirin (ASP) therapy and estimates the strength of this association. A case-crossover design was employed, in which individuals who experienced the outcome also served as their own controls, with exposure evaluated during a pre-event period. Additionally, a person-day–based analytical approach was used to compare exposure between case and control periods. Among the case group (ASP exposed/unexposed), the distribution was 127/578, while in the control group it was 547/3,968, yielding an odds ratio (OR) of 1.6 (95% CI: 1.29–1.97; z = 4.31; P < 0.0001). The findings suggest a modest association between low-dose aspirin use (100 mg/day) and elevated lactate levels, particularly in its primary indication for secondary prevention of vascular ischemic events. Although the observed risk is relatively low (OR = 1.6), clinical monitoring is advisable, especially when aspirin is co-administered with agents sharing similar toxicological profiles. Incorporating lactate level assessment into therapeutic management plans may enhance patient safety and therapeutic outcomes.

Assessing erythrocyte acid resistance is a key part of understanding the effects of toxicants on the blood. The objective of this research is to examine both the isolated and combined effects of cadmium, lead, and zinc ions from contaminated drinking water on the acid resistance of erythrocytes in laboratory rats. This investigation was conducted in the Laboratory of Anatomy, Physiology, and Histology at Chechen State University in Grozny, Russia. The study used laboratory rats weighing 100-150 grams, bred in the university’s vivarium. Exposure to metals altered erythrograms, with a noticeable increase in the proportion of erythrocytes with lower resistance and a reduction in hemolysis time. The most considerable alterations were observed after prolonged exposure to Pb2+, Cd2+, Zn2+, and their mixture. After 30 days of exposure to these ions, the peak times for erythrograms were recorded as 0.5 minutes for Pb2+, 1.0 minutes for Zn2+, and 1.5 minutes for Cd2+. The percentage of erythrocytes undergoing hemolysis at these times was significantly higher, being three times more than the control for Pb2+ and Zn2+, and comparable to the control for Cd2+ (36%). Hemolysis times were notably shorter—2.5 minutes for Pb2+ and Zn2+, and 4.5 minutes for Cd2+. By the end of the 30 days, all rats in the heavy-metal exposure group had died. The findings indicate that prolonged exposure to heavy metals induces significant changes in the erythrocyte population and their acid resistance.